【 Main Ingredients 】 Lincomycin Hydrochloride

【 Appearance 】 This product is a clear liquid ranging from colorless to slightly yellow or slightly yellow green in color.

Pharmacological effects: Lincomycin belongs to the Lincomidine antibiotic family and is a bacteriostatic agent. Sensitive bacteria include Staphylococcus aureus (including penicillin resistant strains), Streptococcus, Streptococcus, Pneumococcus, Bacillus anthracis, Streptococcus suis, and certain Mycoplasma

Mycoplasma hyopneumoniae, Mycoplasma hyorhinis, Mycoplasma hyorhinis), Leptospira, and anaerobic bacteria (such as Clostridium, Clostridium tetani, Clostridium perfringens, and actinomycetes). Mainly acting on the 50S subunit of bacterial ribosomes, by inhibiting

The elongation of peptide chains affects protein synthesis and exerts antibacterial effects.

After intramuscular injection, pharmacokinetics showed rapid absorption. A single intramuscular injection of 11mg/kg in pigs resulted in a peak blood concentration of 6.25 μ g/ml. The plasma protein binding rate is 57% to 72%. It is widely distributed in the body, with an apparent distribution volume of 2.8L/kg in pigs. broad

Widely distributed to various body fluids and tissues (including bones), with the highest concentration in the liver and kidneys, and tissue drug concentrations several times higher than serum concentrations during the same period. Can enter the placenta, but not easily penetrate the blood-brain barrier, and drugs are also difficult to get into the cerebrospinal fluid during inflammation

To achieve effective concentration. Can be distributed to milk, with the same concentration in milk as in plasma. Some drugs are metabolized in the liver, and the drug prototype and its metabolites are excreted through bile, urine, and milk. The excretion of feces can be delayed for several days, so it has an impact on sensitive microorganisms in the intestine

inhibition.

[Drug Interactions] (1) When used in combination with gentamicin, it has a synergistic effect on Gram positive bacteria such as Staphylococcus and Streptococcus.

(2) Combined with aminoglycoside and peptide antibiotics, it may enhance the blocking effect on the neuromuscular junction. When used in combination with erythromycin, it has an antagonistic effect because the site of action is the same, and erythromycin has a higher affinity for the 50S subunit of bacterial ribosomes

This product is strong.

(3) Not suitable for combination with antidiarrheal drugs that inhibit intestinal peristalsis and contain kaolin.

(4) There are compatibility taboos with kanamycin, neomycin, etc.

[Function and Use] Lincolylamine antibiotics. Used for Gram positive bacterial infections,

It can also be used for infections such as swine spirochetes and mycoplasma.

【 Usage and Dosage 】 Intramuscular injection: One dose, 0.033ml per 1kg body weight, once a day for pigs; 0.033ml for dogs and cats, twice a day, for 3-5 consecutive days.

Adverse reactions: It has a neuromuscular blocking effect.

【 Precautions 】 Intramuscular injection may cause transient diarrhea or soft stool. Although rare, necessary measures should be taken to prevent dehydration if it occurs.

[Rest period] 2 days for pigs.

[Specification] 100ml: 30g calculated based on C18H34N2O6S

【 Packaging 】 100ml/bottle, 60 bottles/box

【 Storage 】 Sealed storage.

[Approval number] Veterinary drug number 170611769

Wuhan Liyao Pharmaceutical Co., Ltd. (Sino foreign joint venture)