【 Main Ingredients 】 Enrofloxacin

【 Appearance 】 This product is a clear liquid that is almost colorless to light yellow in color.

Pharmacological effects: Enrofloxacin is a broad-spectrum bactericidal drug specifically designed for fluoroquinolone animals. It has good effects on Escherichia coli, Salmonella, Klebsiella, Brucella, Pasteurella, Actinobacillus pleuropneumoniae, Corynebacterium erysipelas, Proteus mirabilis, Serratia marcescens, Corynebacterium pyogenes, Bordetella septica, Staphylococcus aureus, Mycoplasma, Chlamydia, etc. It has weak effects on Pseudomonas aeruginosa and Streptococcus, and weak effects on anaerobic bacteria. Has a significant antibacterial effect on sensitive bacteria. The antibacterial mechanism of this product is to inhibit bacterial DNA gyrase, interfere with bacterial DNA replication, transcription, and repair recombination, and prevent bacteria from growing and reproducing normally and dying.

Most animals can absorb this product well when taken orally in pharmacokinetics. The bioavailability of chicken oral administration is 62.2%~84%, widely distributed in the avian body, and can easily enter tissues and body fluids (including bones). Except for cerebrospinal fluid, the drug concentration in almost all tissues is higher than that in plasma. Liver metabolism mainly involves the removal of 7-piperazine ring ethyl to produce ciprofloxacin, followed by oxidation and glucuronic acid binding. It is mainly excreted through the kidneys (through tubular secretion and glomerular filtration), with 15% to 50% excreted in its original form in the urine. The elimination half-life of this product for chicken oral administration is 9.1-14.2 hours.

Drug Interactions

(1) This product has a synergistic effect when used in combination with aminoglycosides or broad-spectrum penicillin.

(2) Heavy metal ions such as Ca2+, Mg2+, Fe3+, and AI3+can chelate with this product, affecting absorption.

(3) When combined with theophylline and caffeine, changes in protein binding rate can lead to a decrease in plasma protein binding rate, abnormal increase in the concentration of theophylline and caffeine in the blood, and even symptoms of theophylline poisoning.

(4) This product has an inhibitory effect on hepatic enzymes, which can reduce the clearance rate of drugs mainly metabolized in the liver and increase blood drug concentration.

[Function and Use] Quinolone antibiotics. Used for bacterial diseases and mycoplasma infections.

【 Usage and Dosage 】 Mixed drink: 0.5~0.75ml per IL water for poultry.

Adverse reactions

(1) Degenerate the cartilage of young animals, affecting bone development and causing limping and pain.

(2) The reactions of the digestive system include loss of appetite, diarrhea, etc.

【 Precautions 】

(1) Poultry that lays eggs for human consumption shall not be used during the egg laying period.

(2) Black bone chicken is prohibited.

[Rest period] Poultry for 8 days.

[Specification] 10%

[Packaging]

[Storage] Store in a dark and sealed manner.

[Approval number] Veterinary drug number 170611298

Wuhan Liyao Pharmaceutical Co., Ltd