【 Appearance 】 This product is a colorless or almost colorless clear liquid, slightly viscous.

Pharmacological effects: Ivermectin has a good killing effect on nematodes in the body and arthropods on the body surface. The mechanism of its deworming effect is to promote the release of gamma aminobutyric acid (GABA) from presynaptic neurons, thereby opening GABA mediated chloride ion channels. Ivermectin also exhibits selectivity and high affinity towards glutamate mediated chloride ion channels located near GABA mediated sites in invertebrate neurons and muscle cells, thereby interfering with signal transmission between neurons and muscles, causing the parasite to relax and paralyze, leading to death or expulsion from the body. The inhibitory interneurons and excitatory motor neurons of nematodes are their sites of action, while the site of action of arthropods is the neuromuscular junction. The expulsion rate of adult and fourth stage larvae of blood lance nematodes, Oster nematodes, Cooper nematodes, hairy roundworms (including Aedes furus), roundworms, upside down nematodes, fine necked nematodes, hairy head nematodes, esophageal mouth nematodes, net tail nematodes, and sheep Charcot nematodes in cattle and sheep is 97% to 100%. It is also effective for arthropods such as maggots, mites, and lice. The therapeutic effect on chewing lice and sheep ticks and flies is slightly inferior. Ivermectin is also highly effective against ticks and flies breeding in feces. Although the drug cannot immediately kill ticks, it can affect feeding, molting, and egg laying, thereby reducing reproductive capacity. The effect on blood flies is similar. The elimination rate of roundworms, red pig roundworms, orchid roundworms, hairy head nematodes, esophageal mouth nematodes, posterior roundworms, toothed tail nematodes and immature worms in pigs is 94% to 100%. It is also highly effective against intestinal trichinella (ineffective against muscular trichinella) and has a good control effect on pig blood lice and pig scabies mites. It is ineffective against flukes and tapeworms.

The pharmacokinetics of ivermectin vary significantly depending on the animal species, dosage form, and administration route. The bioavailability of subcutaneous injection is higher than that of oral administration, but oral administration absorbs more quickly than subcutaneous injection. After absorption, it can be well distributed to most tissues, but it is not easy to enter the cerebrospinal fluid. The apparent distribution volumes of cattle, sheep, and pigs are 0.45-2.4L/kg, 4.6L/kg, and 4 L/kg, respectively. Most animals have a longer half-life, with cattle, sheep, and pigs having a half-life of 2-3 days, 2-7 days, and 0.5 days, respectively. This product undergoes metabolism in the liver, mainly hydroxylation in cattle and sheep, and methylation in pigs. Mainly excreted from feces, less than 5% is excreted in its original form or metabolic products from urine. Up to 5% of the administered dose is excreted from the milk of lactating female livestock.

Drug interactions: Simultaneous use with ethamine may result in severe or fatal encephalopathy.

[Function and Use] Macrolide class antiparasitic drugs. Used for preventing and controlling livestock nematode diseases, mite diseases, and other parasitic insect diseases.

【 Usage and Dosage 】 Subcutaneous injection: One dose, 0.02ml per 1kg body weight for cattle and sheep; Pig 0.03ml.

Adverse reactions

(1) When used to treat cowhide fly larvae disease, if the killed larvae are in critical areas, it will cause serious adverse reactions.

(2) During injection, there may be discomfort or temporary edema at the injection site.

【 Precautions 】

(1) Cattle and sheep that produce milk for human consumption are not allowed to be used during the lactation period.

(2) Each subcutaneous injection point should not exceed 10ml.

(3) Ivermectin is highly toxic to shrimp, fish, and aquatic organisms. Residual drugs and packaging should not contaminate water sources.

[Rest period] Cattle and sheep for 35 days, pigs for 28 days.

[Specification] 100ml: 1000mg based on ivermectin (H2B1a+H2B1b)

【 Packaging 】 100ml/bottle, 60 bottles/box

[Storage] Store in a dark, sealed, and dry place.

【 Validity Period 】 2 years

[Approval Number] Veterinary Medicine Character 170611128

Wuhan Liyao Pharmaceutical Co., Ltd